Ki is a nuclear protein associated with cellular proliferation in normal or leukemic conditions that can help identify more aggressive diseases and is usually evaluated with immunohistochemistry. The aim of this was to assess Ki expression on mature B-cell neoplasms samples with flow cytometry immunophenotyping. Ki expression was evaluated with flow cytometry. Ki expression was higher in mantle cell lymphoma, Burkitt lymphoma, and diffuse large B-cell lymphoma cases. It was also associated with CD38 mean fluorescence intensity.
It has been shown that glomerular visceral epithelial cells VEC proliferate during glomerulogenesis, but differentiated VEC of the fetal kidney do not. It is also recognized that the proliferative capacity of the VEC in mature kidneys is very limited, and according to some investigators, may be completely absent. The basis for this remains unknown. Cell proliferation is controlled by cell cycle-related proteins, of which one class, the cyclin kinase inhibitors CKI , cause cell cycle arrest and inhibit proliferation. A role for CKI in kidney development is not known.