Hundreds of different types of mutations in these genes have been identified, some of which have been determined to be harmful, while others have no proven impact. Harmful mutations in these genes may produce a hereditary breast-ovarian cancer syndrome in affected persons. Having a high-risk mutation does not guarantee that the woman will develop any type of cancer, or imply that any cancer that appears was actually caused by the mutation, rather than some other factor. High-risk mutations, which disable an important error-free DNA repair process homology directed repair , significantly increase the person's risk of developing breast cancer , ovarian cancer and certain other cancers. Not all mutations are high-risk; some appear to be harmless variations.
10 Things to Know About BRCA Genes | Texas Oncology
Genes are parts of DNA passed down from your mother and father. They carry information that determine your unique traits, such as height and eye color. Genes are also responsible for certain health conditions. Women with a mutated BRCA gene have a higher risk of getting breast or ovarian cancer. Men with a mutated BRCA gene are at a higher risk for getting breast or prostate cancer. Other factors, including your lifestyle and environment, can affect your cancer risk.
Patients are becoming increasingly aware of the BRCA genes. However, many questions still exist about what they are and their link to hereditary breast and ovarian cancer, as well as other cancers. Here are answers to commonly asked questions.
Metrics details. Identification of BRCA mutations in breast cancer BC patients influences treatment and survival and may be of importance for their relatives. Testing is often restricted to women fulfilling high-risk criteria. However, there is limited knowledge of the sensitivity of such a strategy, and of the clinical aspects of BC caused by BRCA mutations in less selected BC cohorts.